Sprint hf trial
WebThe Systolic Pressure Interventional Trial (SPRINT) represents an important clinical trial to inform practice in the treatment of hypertension. The trial randomized over 9,000 subjects age >50 without diabetes to either a treatment systolic blood pressure goal of ≤120 mmHg or the currently accepted standard 140 mmHg. Web12 Jan 2024 · SPRINT was a randomized, single blinded (outcome adjudicators were blinded to treatment assignment) treatment trial with participants randomized to a systolic blood-pressure target of either less than 140 mm Hg (the standard-treatment group) or less than 120 mm Hg (the intensive-treatment group). Following randomization, baseline …
Sprint hf trial
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Web9 Nov 2015 · The trial was designed to identify serious adverse effects expected to be related to more intensive treatment of hypertension. 2 The SPRINT protocol prespecified conditions of interest, including orthostatic hypotension, syncope, bradycardia, electrolyte abnormalities, injurious falls, and acute kidney injury or failure. WebSPRINT-MIND was a pre-planned sub-study of the SPRINT trial. To test the hypothesis that intensive blood pressure reduction in this cohort would reduce the primary outcome of probable all-cause dementia, they planned cognitive assessments alongside the main trial at baseline, every 2-years, and at study completion.
Web23 May 2016 · Updated analysis of heart failure events (SPRINT HF sub-study) again showed significant differences between the intensive and standard group, with a 36% reduction of acute decompensated heart failure events in the former group. ... Keep in mind that the intensive group in the SPRINT trial was followed very closely – if intensifying … WebKey Points. Question Does intensive blood pressure control reduce the occurrence of dementia?. Findings In this randomized clinical trial that included 9361 adults with hypertension, randomization to a systolic blood pressure target of less than 120 mm Hg compared with less than 140 mm Hg resulted in a rate of probable dementia of 7.2 vs 8.6 …
Web3 Apr 2024 · PROMPT-HF is a pragmatic, single health-system, EHR-based, cluster-randomized (by provider), comparative effectiveness trial. Retrospectively, the top 100 providers caring for HFrEF patients in the outpatient setting (physicians or advanced practice providers) were identified. WebThe Systolic Blood Pressure Intervention Trial is the first large prospective randomized controlled trial to demonstrate the benefit of an intensive systolic blood pressure (SBP) treatment target (<120 mm Hg) compared to a standard target (<140 mm Hg) in reducing cardiovascular morbidity and mortality and all-cause mortality in high-risk hypertensive …
Web25 Nov 2015 · SPRINT was a large randomized controlled trial with over 9,000 non-diabetic patients, funded by the NIH, to study the effect of intensive blood pressure control on cardiovascular health.
Web1 Aug 2024 · Methods: This analysis included 8164 participants (mean age, 67.9 years; 35.3% women; 31.2% blacks) with hypertension but no diabetes mellitus from the SPRINT trial (Systolic Blood Pressure Intervention Trial): 4086 randomly assigned to intensive BP lowering (target SBP <120 mm Hg) and 4078 assigned to standard BP lowering (target … change address for taxesWeb21 Sep 2010 · The Systolic Blood Pressure Intervention Trial (SPRINT) is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will reduce cardiovascular disease (CVD) risk. change address for us mailWeb23 Aug 2024 · The CREDENCE trial showed a similar benefit in CKD patients with type 2 DM; this trial extends the benefit to patients without DM and with lower GFR. Similar results have been reported for heart failure reduction among patients with heart failure and reduced ejection fraction with these drugs, independent of DM status. change address for upsWeb7 Nov 2024 · The STRONG-HF trial was a multinational, open-label, randomized, parallel-group trial of participants admitted with acute heart failure not on full doses of HF guideline-directed medical therapy (GDMT). Patients were randomized in a 1:1 fashion to high-intensity up-titration (n = 542) or usual care (n = 536). hardees raisin figurinesWeb30 Aug 2024 · The SPRINT trial documented reduction in cardiovascular events with a systolic blood pressure target <120 mm Hg; however, this occurred at a cost of increased kidney injury. References: Zhang W, Zhang S, Deng Y, et al., on behalf of the STEP Study Group. Trial of Intensive Blood-Pressure Control in Older Patients With Hypertension. hardees qatar lunch offerWeb26 Jul 2024 · The study looked at 454 participants in the SPRINT trial who received follow-up MRIs at a median of 3.98 years post-randomization. Results showed that in the intensive-treatment group, WML volume increased by 0.28 cm3 vs. 0.92 cm3 in the standard treatment group. Total brain volume decreased by 27.3 cm3 in the intensive treatment … hardees raisins worthWeb10 Nov 2024 · The SPRINT (Systolic Blood Pressure Intervention Trial) demonstrated the effectiveness of treating systolic blood pressure to levels well below those previously recommended in United States and European blood pressure guidelines. 1 The SPRINT results have informed guideline committees in recommending treatment to systolic blood … hardees pound puppies from 1986