High dose statins in elderly

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August undefined, 2024

WebThe dose-response for statins on new onset of diabetes suggests elderly women should not be exposed to higher doses of statins. Elderly women currently taking statins … Web25 de set. de 2014 · High doses or high-potency statins in elderly people may not increase effectiveness, but may increase the risk of adverse effects such as muscle …

New-Onset Diabetes After Statin Exposure in Elderly Women: The …

Web19 de dez. de 2024 · The MIRACL study looked at the effects of a high dose of Lipitor on 3086 patients in the hospital after angina or nonfatal MI and followed them for 16 weeks. 37 According to the abstract: ... My … Web23 de out. de 2015 · While the Study Assessing Goals in the Elderly (SAGE) showed similar efficacy of higher-intensity statins, it also showed greater clinical risks. The 893 older adults with CAD and ischemia enrolled in SAGE were randomized to atorvastatin-80 mg versus pravastatin-40 mg. Higher-dose statin therapy was associated with 23% reduced … sharon gooch

Cholesterol Management: ACC/AHA Updates Guideline AAFP

WebManaging hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin Zhen Wang, Junbo GeDepartment of Cardiology, Zhongshan Hospital, Shanghai, People's Republic of ChinaAbstract: Coronary heart disease (CHD) is the leading cause of death worldwide. The efficacy and safety of … WebNational Center for Biotechnology Information Web10 de fev. de 2024 · High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006; 355:549–559. doi: 10.1056/NEJMoa061894 Crossref Medline Google Scholar; 3. Heart protection Study Collaborative group. ... Statins for secondary prevention in elderly patients. J Am Coll Cardiol. sharon gooch ohio

New-Onset Diabetes After Statin Exposure in Elderly Women: The …

Safe use of statins in elderly people - Wiley Online Library

Web14 de abr. de 2024 · In the IMPROVE-IT trial, researchers showed adding ezetimibe to moderate-intensity statins vs. moderate intensity statin alone in ASCVD patients resulted in lower LDL cholesterol levels and reduced ASCVD events, especially in those older than age 75 years. 1 However, most guidelines recommend high-intensity statin therapy for … Web3 de mar. de 2024 · Mechanism of action. The beneficial effects of statins result, at least in part, from direct inhibition of HMG-CoA reductase. Citation 8 This inhibition reduces endogenous cholesterol biosynthesis and increases the expression of LDL receptors responsible for LDL-C uptake and clearance. Citation 8 These do not seem to be the … sharon gomez crnpWebThis risk can be heightened by factors such as high cholesterol, diabetes and high blood pressure, even in those who are otherwise seemingly healthy.” “Previous clinical trials – … sharon gonzales facebook

"Web18 de mar. de 2024 · Statins are drugs that can lower your cholesterol. They work by blocking a substance your body needs to make cholesterol. Lowering cholesterol isn't the only benefit associated with statins. These medications have also been linked to a lower risk of heart disease and stroke. These drugs may help stabilize the plaques on blood … " - High dose statins in elderly

High dose statins in elderly

Atorvastatin: a medicine to treat high blood cholestesterol - NHS

Web5 de mar. de 2024 · High dose statins in plaque ... simvastatin (Zocor), and rosuvastin (Crestor) Should be considered for all patients: the elderly, symptomatic CVD, coronary heart disease, occlusive arterial disease ... QUESTION 7 A 44-year-old patient with familial hypercholesterolaemia is being treated with high dose nicotinic ... Web8 de mai. de 2024 · Statins have proved beneficial for the prevention of cardiovascular disease in adults, 1, 2, 3 but patients >75 years have been underrepresented in …

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Web30 de out. de 2024 · The incidence and prevalence of atherosclerosis increase with age and the number of cardiovascular events is higher in elderly patients. The most efficient … Web2 de jan. de 2024 · Recommended statins based on low-density lipoprotein cholesterol (LDL-C) before treatment is 70-189 mg/dl in the age range of 40-75 years in the ACC/AHA who require a ≥7.5% 10-year risk to be eligible. In contrast, in the NICE-UK, which apply to 30-84 years, high-intensity treatment is recommended regardless of LDL-C if 10-year …

Webthere seems no controversy in initiation of statins in patients for primary prevention up to 80 years of age. Elderly people are at highest risk of cardiovascular morbidity and mortality, … WebStatins are drugs that lower your cholesterol. But if you are age 75 or older and you haven’t had symptoms of heart disease, statins may be a bad idea. Here’s why: Adults age 75 …

WebRisk increased with increasing dose of statin from the hazard ratio of 1.17 (95% CI 0.84-1.65) for the lowest dose to 1.51 (95% CI 1.14-1.99) for the highest dose. Conclusion: The dose-response for statins on new onset of diabetes suggests elderly women should not be exposed to higher doses of statins. Web3 de abr. de 2024 · Importantly, however, the combination of moderate-intensity statins and ezetimibe was associated with lower rates of intolerance-related drug discontinuation or dose reduction compared with high-intensity statin monotherapy among patients in the elderly group (2.3% vs 7.2%; P = 0.010) and in those younger than 75 (5.2% vs 8.4%; P …

WebStatin treatment reduces cardiovascular morbidity and mortality in middle-aged adults. However, few studies have included older individuals, particularly those aged 80 years or …

WebRhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per … sharon goodchild mirfieldWebFor primary prevention of CVD, high-intensity statin treatment (atorvastatin 20 mg daily) should be considered in people (without the need for a formal risk assessment): With … population statewise in indiaWeb19 de jul. de 2024 · A specific high-dose preparation (4 grams per day of icosapent ethyl or 1800 mg per day of highly purified EPA) has been found to reduce the risk of heart attack, stroke, need for stent of bypass surgery, and cardiac death when used with a statin in people who have mild hypertriglyceridemia (149 to 500 mg/dL) and either established … sharon goodchild obituaryWeb18 de mai. de 2024 · Given the compelling data supporting statin therapy in the high-risk elderly population, ... Jukema JW, de Craen AJ, Eisenberg MJ. Statins for secondary … sharon goodellWeb12 de mar. de 2024 · Khush KK, Waters DD, Bittner V, et al. Effect of high-dose atorvastatin on hospitalizations for heart failure: subgroup analysis of the Treating to New Targets (TNT) study. Circulation 2007; 115:576. Horwich TB, MacLellan WR, Fonarow GC. Statin therapy is associated with improved survival in ischemic and non-ischemic heart … sharon goodchildWeb18 de jun. de 2024 · The concentration of LDL cholesterol was 24 mg/dL lower in those taking the higher dose of atorvastatin, and the risk of having a major cardiovascular event was 22% lower ( P <0.001). But there was no significant effect on all-cause death. 3 In the IDEAL trial (Initiating Dialysis Early and Late), the effect of atorvastatin at a dose of 80 … populations that drive medicaid costWeb18 de mar. de 2024 · Statins are drugs that can lower your cholesterol. They work by blocking a substance your body needs to make cholesterol. Lowering cholesterol isn't the … sharon gooding hill